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Isotretinoin (INN) is a medication used and recommended only for treatment of severe acne or cystic. It is a retinoid derivative of vitamin A found in small amounts in the body natural. Oral isotretinoin is labeled with several different trade names, known as Isoface, Oratane, Accutane, Acnotin, Acneral, Roaccutane, Acnemin, Atretin, Dercutane or gel isotretinoin is commonly labeled under the brand names Isotrexin and Isotrex. Systemic isotretinoin may be used for the treatment of skin disorders of acne vulgaris as well as psoriasis, skin cancer, rosacea, lupus erythematosus, among others. Like any drug, shall not exceed the recommended dose should be taken or app.
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Pharmacodynamics
Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). It is very effective in acne treatment because it acts on all the etiological factors of disease: production of sebum, comedogénesis, colonization of the duct with P. acnes. The exact mechanism of action of isotretinoin has not yet been clarified in detail, but it has been established that the improvement observed in the clinical picture of severe acne is associated with dose-related suspension of the activity of the sebaceous glands. On the other hand, has established the dermal inflammatory effect of isotretinoinlied sparingly and under medical supervision due to the high level of toxicity and side effects, even after leaving the medication.
Pharmacokinetics
The oral isotretinoin is better absorbed when administered after a meal, this due to its lipid solubility and is more than enough to absorb fat 1g entirely because they are only 20mg of isotretinoin given that 1g = 1000mg; according to studies concluded that it can be doubled. Have detected at least 3 metabolites as a result of taking isotretinoin, 4-oxo-isotretinoin, retinoic acid and acid 4-oxo-retinoic. In addition, isotretinoin is irreversibly oxidized to 4-oxo-isotretinoin. These metabolites are excreted through urine and feces, by about half. Isotretinoin has a terminal elimination half-life of about 19 hours while for the 4-oxo-isotretinoin is 29 hours.
Teratogenicity
Isotretinoin is a teratogenic drug so there is a high risk of causing fetal malformations in the case where the patient gets pregnant while under treatment. No teratogenic effects have been reported following drug concentrations in semen of patients. In general, the recommended dosage pregnancy tests monthly for women at risk of becoming pregnant. Similarly, patients treated with isotretinoin should not donate blood because of possible risk of a transfusion is made to a pregnant woman.
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